Head and Neck Cancer Signs and Symptoms

Head and neck cancers affect the tissues of the mouth, throat, sinuses, and surrounding areas. They can impact crucial functions like breathing, swallowing, and talking.
There are several types of head and neck cancer, with nuanced symptoms. Noticing these symptoms and reporting them to your healthcare provider early can improve your treatment outcomes.
Symptoms of Head and Neck Cancer
- A lump in the neck, jaw, or mouth
- Swelling under the chin or jawbone
- Sores or red or white patches in the mouth or the throat that won’t heal
- Difficulty or pain when swallowing
- Pain in the upper teeth or problems with dentures
- Pain in the face, neck, or chin that does not go away
- Unexpected paralysis of the face muscles
- An unexplained change in the voice or hoarseness
- Ear pain or hearing loss
- Frequent headaches
Other less-common symptoms of head or neck cancer can include frequent earaches and a chronic sinus infection that doesn’t respond to antibiotics. Issues with the mouth, including unusual bleeding or numbness in the mouth or tongue could be signs of head or neck cancer.
Types of Head and Neck Cancer
- Oral Cancer Oral cancer develops in the mouth and may affect the lips, tongue, cheek, and the floor or roof of the mouth. It’s one of the most common types of head and neck cancer.
- Oropharyngeal Cancer This type of cancer occurs in the oropharynx, or the middle section of the throat. It may include the base of the tongue, tonsils, and back of the throat.
- Nasopharyngeal Cancer This rare type of cancer occurs in the nasopharynx, behind the nose and back of the throat. It’s often diagnosed in later stages.
- Hypopharyngeal Cancer This cancer forms in the hypopharynx, the lower part of the throat surrounding the larynx (voice box).
- Nasal Cavity and Paranasal Sinus Cancer These uncommon cancers occur in the nasal cavity or sinuses.
- Salivary Gland Cancer This rare cancer occurs in the salivary glands, including those near the mouth and jaw. It has multiple subtypes.
- Tonsil Cancer This is a subtype of oropharyngeal cancer that affects the tonsils and is often linked to HPV infection or tobacco use.
When to See a Doctor
Detecting cancer early often leads to more successful treatment outcomes, so you don’t want to ignore any sign of a potential head and neck cancer. Although symptoms of head and neck cancer could be caused by many other things, if you have any of them, especially a chronic sore throat or a new lump in the head or neck, it’s important to ask your doctor about the possibility of cancer.
Your doctor is likely to examine the head and neck area to feel for abnormalities and may use mirrors and lights inside the mouth and throat to explore areas that are harder to see. Blood or urine tests may also be performed.
- Endoscopy This thin lighted tube with a camera at the tip can help a doctor explore areas of the head and neck, including the sinuses, that are harder to reach.
- Diagnostic Imaging A radiologist can take images of your throat that may include CT scans, PET scans, MRIs, or an X-ray called a Panorex (panoramic radiograph) that shows the upper and lower jaw and the sinuses.
- Biopsy A surgeon may remove a small amount of tissue from an area where cancer is suspected. A pathologist examines the sample and consults with team members to make a diagnosis.
If there is a diagnosis of cancer, your doctor will consult with you to determine the best options for treating the cancer, based on its location and how far it has progressed.
The Takeaway
- Head and neck cancer is a group of cancers that develop in the tissues of the head and neck, including the mouth, throat, sinuses, and salivary glands.
- Early detection of head and neck cancer is crucial for better outcomes, and symptoms can sometimes be mistaken for those of other conditions.
- Common signs include persistent lumps, sores that don’t heal, difficulty swallowing, voice changes, and unexplained pain.
- If you notice these signs and symptoms, especially sore throat or a new lump in the head or neck, talk to your doctor immediately.
Resources We Trust
- Mayo Clinic: What is mouth cancer? A Mayo Clinic expert explains
- Cancer Care: Coping With Oral and Head and Neck Cancer
- Head and Neck Cancer Alliance: Oral, Head & Neck Self-Exam Guide
- Support for People With Oral and Head and Neck Cancer: Find a Local Chapter Near You
- Memorial Sloan Kettering: Resources for Head and Neck Cancer Survivors
- Head and Neck Cancer. Cleveland Clinic. September 30, 2024.
- Head and Neck Cancer Symptoms and Signs. Memorial Sloan Kettering Cancer Center.
- Head and Neck Cancers. National Cancer Institute. May 25, 2021.
- Head and Neck Cancers. American Cancer Society.
- Head and neck cancer types. City of Hope. May 19, 2022.
- Head and Neck Cancer. MedlinePlus.
- Head and neck cancer symptoms. City of Hope Cancer Center. June 23, 2022.
- What is an otolaryngologist? City of Hope Cancer Center. July 25, 2023.
- Head and Neck Cancer Diagnosis. Memorial Sloan Kettering Cancer Center.

Conor Steuer, MD
Medical Reviewer
Conor E. Steuer, MD, is medical oncologist specializing in the care of aerodigestive cancers, mesothelioma, and thymic malignancies and an assistant professor in the department of hematology and medical oncology at the Emory University School of Medicine in Atlanta. He joined the clinical staff at Emory's Winship Cancer Institute as a practicing physician in July 2015. He currently serves as chair of the Lung and Aerodigestive Malignancies Working Group and is a member of the Discovery and Developmental Therapeutics Research Program at Winship.
Dr. Steuer received his medical degree from the New York University School of Medicine in 2009. He completed his postdoctoral training as a fellow in the department of hematology and medical oncology at the Emory University School of Medicine, where he was chief fellow in his final year.
He has been active in research including in clinical trial development, database analyses, and investigation of molecular biomarkers. He is interested in investigating the molecular biology and genomics of thoracic and head and neck tumors in order to be able to further the care of these patient populations. Additionally, he has taken an interest in utilizing national databases to perform clinical outcomes research, as well as further investigate rare forms of thoracic cancers.
Steuer's work has been published in many leading journals, such as Cancer, the Journal of Thoracic Oncology, and Lung Cancer, and has been presented at multiple international conferences.
